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. Author manuscript; available in PMC: 2010 Oct 28.
Published in final edited form as: Psychopharmacology (Berl). 2009 Mar 10;204(4):667–677. doi: 10.1007/s00213-009-1497-4

Figure 6.

Figure 6

Effects of ketamine on response rates before (pre-chronic; circles) and during chronic flunitrazepam treatment with either one (upper panel) or two (lower panel) injections administered daily prior to sessions. Cumulative dose-effect curves for ketamine were determined under two different conditions. Before determination of one of these dose-effect curves, 1 mg/kg of flunitrazepam was administered 1 hr before sessions (squares); before determination of the other dose-effect curve, flunitrazepam was last administered 25 hr before sessions (triangles). Abscissae: cumulative dose of ketamine in mg/kg body weight. Points above V were determined following administration of saline on the first cycle. Ordinates: average response rates expressed as a percentage of control rates determined immediately before chronic treatment (± 1 SEM).