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. Author manuscript; available in PMC: 2010 Oct 28.
Published in final edited form as: Psychopharmacology (Berl). 2009 Mar 10;204(4):667–677. doi: 10.1007/s00213-009-1497-4

Figure 7.

Figure 7

Effects of midazolam (left panel), pentobarbital (middle panel) or morphine (right panel) on response rates before and during chronic flunitrazepam treatment in which two injections were administered daily. Cumulative dose-effect curves were determined before chronic treatment (pre-chronic; circles) and either 1 hr (squares) or 25 hr (triangles) after the last injection of flunitrazepam. Abscissae: cumulative dose in mg/kg body weight. Points above V were determined following administration of saline on the first cycle. Ordinates: average response rates expressed as a percentage of control rates determined immediately before chronic treatment (± 1 SEM).