. Author manuscript; available in PMC: 2010 Oct 28.

Published in final edited form as: Psychopharmacology (Berl). 2009 Mar 10;204(4):667–677. doi: 10.1007/s00213-009-1497-4

Table 2.

Control response rates (± SEM) in 8 rats before, during and after chronic flunitrazepam treatment. Each value represents the mean rate obtained during 10 training sessions under the same treatment condition; no drug was administered during training sessions. Weeks of treatment indicate the time since the beginning of treatment with a single injection of 1 mg/kg of flunitrazepam or the time since termination of treatment.

Treatment	Response rate (responses/sec)

Before chronic flunitrazepam
Last 10 training sessions	0.66 ± 0.05

1 mg/kg flunitrazepam
Weeks 2-3	0.75 ± 0.02
Weeks 5-7	0.82 ± 0.03^*

2 × 1 mg/kg flunitrazepam
Weeks 9-10	0.97 ± 0.03^*
Weeks 18-21	0.77 ± 0.04

Discontinuation of treatment
First 10 training sessions	0.45 ± 0.06^*
12 weeks after treatment	0.55 ± 0.03

indicates that rate is significantly different from rate determined before chronic treatment.