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Biphasic effect of 2-APB on Icrac.A) During thapsigargin-(TG)-activated store-operated Ca2+ entry in HEK293 cells, addition of 3 or 10 μM 2-APB enhances entry, whereas addition of 30 or 50 μM inhibits. B) Icrac in HEK293 cells overexpressing Orai1 and STIM1 is augmented by 20 μM 2-APB but inhibited by 50 μM. Adapted from (48).
