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. 2010 Aug;10(4):209–218. doi: 10.1124/mi.10.4.4

Table 1.

Small-molecule Inhibitors of Store-operated Calcium Entry

Inhibitor type Species Description Reference
Direct channel inhibitors Lanthanides Potent and relatively specific inhibitors (effective at ~ 0.1 –1.0 μM) (4, 59)
2-APB Relatively non-specific (effective at ~30 μM) (3)
Analogs of APB (“improved”) Improved potency/specificity (effective at ~ 0.6 6.6 μM) (79)

Mechanism-based inhibitors Nocodazole Microtubule disrupter ~ 10 μM; however, inhibition is incomplete (60)
ML-9 Inhibits STIM translocation, not through MLCK inhibition; (~10 μM) (64)
2-APB Weakly inhibits STIM translocation (~ 10 100 μM) (48)

Mechanism not known BTPs Also activate TRPM4 (83, 103)
Synta66 (102)
Other recently described small molecules [See (92)]
Relatively non-specific inhibitors [See (3)]