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. 2010 Jun;1(6):597–604. doi: 10.1177/1947601910377798

Figure 1.

Figure 1.

MYC inactivation has different outcomes in different types of tumors, including proliferative arrest, differentiation, apoptosis, and/or cellular senescence. Although the consequences are different for each type of tumor, proliferative arrest, apoptosis, and differentiation/senescence appear to be common mechanisms. Tumors can also become dormant, partially regress, and reoccur.