Table 2.

Histopathologic Studies

Group	Description	n	Hepatocyte size units (mean ± S.D.)			pa	No. of labeled hepatocytes per 100 hepatocytesb (mean ± S.D.)	pa
			Before	2 weeks	Sacrifice		Sacrifice
1	PCS	6	0.365 ± 0.048		0.141 ± 0.020	—	13.8 ± 1.6	—
2	PCS + BF	10	0.358 ± 0.070		0.158 ± 0.020	NSc	13.9 ± 1.2	NS
3	PCS	10	0.354 ± 0.031		0.154 ± 0.036	—	14.3 ± 1.8	—
4	PCS + BF (staged)	5	0.356 ± 0.063	0.159d ± 0.025	0.158 ± 0.009	NS	15.1 ± 2.9	NS
5	IB	5	0.351 ± 0.034		0.328 ± 0.035	<0.01	1.64 ± 0.3	<0.001
6	PCS + IB	10	0.354 ± 0.048		0.138 ± 0.011	NS	13.8 ± 2	NS
7	PCS + IB (staged)	10	0.358 ± 0.054	0.173d ± 0.036	0.162 ± 0.030	NS	16.1 ± 1.6	NS

^aStatistical comparisons were between Group 2 vs. Group 1 (control) and Groups 4 to 7 at sacrifice vs. Group 3 (control).

^bIn normal unoperated dogs, the labeling is 1.6 ± 0.4 (7).

^cNS, not significant.

^dThe atrophy at 2 weeks was explained by the PCS which was the first stage operation.