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. 2010 Oct 28;5(10):e13713. doi: 10.1371/journal.pone.0013713

Figure 4. Concentration-dependent effect of stilbenoids 1–3 on PGE-2 release from irradiated (UVB 60 mJ/cm2) HaCaT.

Figure 4

Histogram represents the quantity of PGE-2 produced (PGE-2/ total HaCaT proteins pg/µg) according to different treatments. Untreated irradiated (UVB+) and non irradiated (UVB-) HaCaT were used as positive and negative controls, respectively. Indomethacin (Indomet.) at 2.79 µM represented the positive reference (54% inhibition of PGE-2 production). Inhibition percentages of PGE-2 release were calculated by comparison with the positive control: UVB+. Values represent mean ± sd of three independent experiments. Treatment groups were compared by using one way analysis of variance ANOVA post-hoc test. Student paired t test was used to compare each stilbenoid effect to the positive control. Statistical significance (*) was set at p<0.05. Significant differences were observed between each biomarker effect. IC50 were calculated with more points than those represented here on the graph.