Table 1. Summary of the independent samples and tests performed for the association study on chromosome 18.

		Analysis type	# tests
Discovery sample	187 UK families	QTDT	6×2895
Replication sample 1	102 UK families	QTDT	6×24
Replication sample 2	152 US families	QTDT	5×24
Replication sample 3	317 UK DD cases and 287 controls	Allelic & genotypic tests	2×24

A summary of the samples used and the tests conducted in the discovery and replication stages of the association study on chromosome 18. Note, an additional 25 UK families not genotyped for microsatellites, were used in the replication stage of SNP associations, and 3 US families genotyped for microsatellites in the linkage stage failed genotyping for the association stage.