Table 3. Results for any SNPs that replicated in any independent sample.

		Association analysis for minor allelea
SNP	Gene	Discovery familiesb	102 UK familiesb	152 US familiesb	317 UK DD cases and 287 population controlsc
rs11874896	EPB41L3	[-] P<0.001 (PA)	[-] 0.05 (OC-irreg)	n/s	n/s
rs1299348	MC5R	0.006 (OC-irreg)0.005 (OC-choice)0.001 (READ)	0.04 (SPELL)	n/s	0.009 (allelic)0.009 (genotypic)
rs10502812	AK131011	[-] P<0.001 (PD)	n/s	−0.05 (PD)−0.03 (SPELL)	n/s
rs11661879	KIAA0427	0.03 (OC-irreg)0.001 (SPELL)0.02 (PA)	0.04 (SPELL)	n/s	n/s
rs11873029	DYM	0.004 (PD)0.001 (PA)	0.01 (OC-choice)	n/s	0.006 (allelic)0.02 (genotypic)
rs555879	MYO5B	0.03 (PD)0.02 (SPELL)0.002 (PA)	n/s	n/s	0.03 (genotypic)
rs8094327	NEDD4L	0.02 (OC-irreg)0.008 (PD)0.002 (READ)0.04 (SPELL)	n/s	n/s	0.007 (allelic)0.007 (genotypic)
rs12606138	NEDD4L	0.02 (OC-irreg)0.007 (PD)0.002 (READ)0.04 (SPELL)	n/s	n/s	0.005 (allelic)0.002 (genotypic)

^aabsolute values presented are p-values for the minor allele, and the negative sign [-] indicates an association of risk for DD with that allele, else that allele confers protection against DD. n/s means not significant (p-value>0.05) – the actual p-values are available in the supplementary tables;

^bthe acronyms OC-irreg, PD, OC-choice, READ, SPELL and PA in brackets refer to the trait giving association with QTDT;

^cthe terms allelic or genotypic in brackets indicate the allelic or genotypic test for that p-value.