Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Oct 28;5(10):e13709. doi: 10.1371/journal.pone.0013709

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

PMC Copyright notice

Reelin secreted by Cajal-Retzius cells assists the migration of neurons from the upper intermediate zone (IZ) toward the cortical plate (CP). This process requires the activation of ApoER2, Dab1 and Pi3K. The transition from lower IZ to upper IZ is reelin-independent but Pi3K-dependent. Radial glial elongation is also influenced by reelin via activation of VLDLR, Dab1 and Pi3K. NRG1 does not control radial-guided migration in ferret but controls radial glial elongation via activation of erbB3, erbB4 and Pi3K. BLBP expression in radial glial processes is correlated with their elongated morphology and can be upregulated by reelin and NRG1. CP: Cortical Plate; IZ_u-L: Upper and Lower Intermediate Zone; MZ: Marginal Zone.