Table 3. Protective efficacies against heterologous challenge following drug treatment and 3 homologous re-infectionsa.
Group | Parasite used for drug treatment and re-infection | Parasite used for heterologous challenge | No. of protected mice/total no. (%) |
EXP6 | |||
G1 | Pbb | Py | 10/10 (100) |
G2 | Pyc | Pb | 0/10 (0) |
G3 | NTd | Pb | 0/5 (0) |
G4 | NT | Py | 0/5 (0) |
P. berghei- or P. yoelii-infected BALB/c mice were treated with Artemether®. The drug-cured mice were re-infected three times with homologous parasites at 4-week intervals. All mice survived these re-infections. The self-cured mice were then challenged with heterologous parasites.
Pb, P. berghei ANKA.
Py, P. yoelii 17XL.
NT, neither drug-treatment nor infection.