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. 1990 Apr;85(4):1328–1332. doi: 10.1172/JCI114572

Cosegregation of the renin allele of the spontaneously hypertensive rat with an increase in blood pressure.

T W Kurtz 1, L Simonet 1, P M Kabra 1, S Wolfe 1, L Chan 1, B L Hjelle 1
PMCID: PMC296571  PMID: 1969424

Abstract

The spontaneously hypertensive rat (SHR) exhibits alterations in the renin-angiotensin-aldosterone system which are similar to those that characterize patients with "nonmodulating" hypertension, a common and highly heritable form of essential hypertension. Accordingly, we determined whether the inheritance of a DNA restriction fragment length polymorphism (RFLP) marking the renin gene of the SHR was associated with greater blood pressure than inheritance of a RFLP marking the renin gene of a normotensive control rat. In an F2 population derived from inbred SHR and inbred normotensive Lewis rats, we found the blood pressure in rats that inherited a single SHR renin allele to be significantly greater than that in rats that inherited only the Lewis renin allele. To the extent that the SHR provides a suitable model of "nonmodulating" hypertension, these findings raise the possibility that a structural alteration in the renin gene, or a closely linked gene, may be a pathogenetic determinant of increased blood pressure in one of the most common forms of essential hypertension in humans.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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