Table 1.

Natural product compounds active against aromatase in non-cellular assays^a

Compound Code	Source	Assay Type	Activity		Ref.
Alkaloid
1	Casimiroa edulis	DBF enzymeb	3.92	μM IC50	[19]
Chromanones
2	Monodictys putredinis	DBF enzymeb	16.5	μM IC50	[23]
3	Monodictys putredinis	DBF enzymeb	24.4	μM IC50	[23]
Coumarin
4	Xyris pterygoblephara	DBF enzymeb	1.6	μM IC50	[17]
Depsidone
5	Corynespora cassiicola L36	MFC enzymec	5.30	μM IC50	[21]
Fatty Acids
6	Brassica campestris	microsomes	7.80	μg/mL IC50	[13]
7	Brassaiopsis glomerulata	microsomes	7.4	PCA at 20 μg/mL	[14]
Flavonoids
Biflavanone
8	Garcinia kola	DBF enzymeb	11.3	μM IC50	[22]
Chalcone
9	Glycyrrhiza glabra d	Supersomes®	3.8	μM IC50	[9]
Flavanones
10	commerciald	MFC enzymec	0.34	μM IC50	[16]
11	Turnera diffusa	HepG2 cell lysate	18.7	μM IC50	[8]
12	Prunus avium	DBF enzymeb	1.2	μM Ki	[20]
Flavones
13	Turnera diffusa	HepG2 cell lysate	10.8	μM IC50	[8]
14	commerciald	MFC enzymec	10	μM IC50	[16]
15	commerciald	MFC enzymec	11	μM IC50	[16]
16	commerciald	DBF enzymeb	1.0	μM Ki	[20]
17	Prunus avium	DBF enzymeb	2.1	μM Ki	[20]
18	commerciald	DBF enzymeb	5.1	μM Ki	[20]
Isoflavone
19	Trifolium pratense d	Supersomes®	12.5	μM IC50	[10]
Terpenoids
20	Commiphora myrrha	microsomes	0.21	μM IC50	[11]
21	Commiphora myrrha	microsomes	0.32	μM IC50	[11]
Xanthones
22	Garcinia mangostana	microsomes	6.9	μM IC50	[12]
23	Garcinia mangostana	microsomes	5.2	μM IC50	[12]
24	Garcinia mangostana	microsomes	20.7	μM IC50	[12]

^aThe structures of compounds 1 – 24 are shown in Fig. 1.

^bDBF (O-benzylfluorescein benzyl ester) was used as substrate with purified aromatase enzyme.

^cMFC (7-methoxy-4-trifluoromethyl coumarin) was used as substrate with purified aromatase enzyme.

^dThe source of the material in the literature reference was listed as commercial, but this compound is traditionally isolated from a natural product source.