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. Author manuscript; available in PMC: 2010 Oct 28.
Published in final edited form as: Nature. 2010 Feb 25;463(7284):1101–1105. doi: 10.1038/nature08829

Figure 2. Erasure of DNA methylation in different genomic elements in PGCs.

Figure 2

Methylation levels in promoters, exons, introns and intergenic regions in ES cells, Np95-/- ES cells, and various tissues of C57BL/6J and Aid-/- knockout mice are shown based on ratios of methylated to unmethylated BS-Seq reads. Placenta, fetal carcass and PGCs were all collected at E13.5. Note the particularly pronounced effect of Aid deficiency on methylation of introns and intergenic regions.