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. Author manuscript; available in PMC: 2010 Oct 28.

Published in final edited form as: J Med Chem. 2008 Jul 8;51(15):4708–4714. doi: 10.1021/jm800422v

Scheme 2a — ^aReagents and conditions: (a) NaH, BnBr in DMF; (b) 30% KOH/MeOH/THF (2:1:1), reflux; (c) MeLi or isopropyllithium in THF; (d) NaBH₄ in EtOH/THF; (e) NaBH₄, TFA in CH₂Cl₂; (f) (1) BBr₃ in CH₂Cl₂, (2) NaH R₂COCHR₃Br in DMF; (g) (1) oxalyl chloride in CH₂Cl₂, (2) NH₃(g); (h) 1.5 M NaOH in MeOH/THF or 20% TFA in CH₂Cl₂.