Table 1. Baseline characteristics of both the discovery and replication cohorts.
| Discovery cohorts | Replication cohorts | |||||||
| AGES | ARIC | CHS | RS | Australian Twins | UK Twins | BDES | BMES | |
| Original cohort | 5,764 | 15,792 | 5,888 | 7,983 | 2,235 | 8,810 | 2,579 | 3,508 |
| Non-Hispanic whites in original cohort | 11,478 | 4,925 | 7,983 | 2,190 | 8,810 | 2,579 | 3,487 | |
| Total number included in analyses | 2,949 | 6,317 | 1,272 | 4,820 | 1,709 | 1,132 | 2,522 | 1,310 |
| Mean age (years) (SD) [range] | 76.2 (5.4)[66–94] | 60.3 (5.6)[50–72] | 78.4 (4.1)[72–95] | 68.0 (8.2)[55–99] | 22.5 (12.4)[5–90] | 58.1 (10.1)[16–81] | 60.6 (10.8)[43–86] | 66.0 (8.6)[49–93] |
| Proportion female (%) | 57.5 | 52.9 | 62.9 | 59.0 | 57.0 | 97.7 | 55.8 | 58.4 |
| Mean CRAE (µm) (SD) [range] | 139.7(13.4)[74.0–221.4] | 136.1 (14.3)[72.6–203.8] | 140.4 (15.7)[77.6–197.4] | 150.0 (14.4)[98.5–235.4] | 164.2 (13.6)[83.6–205.2] | 163.8 (18.1)[91.0–219.6] | 149.5 (13.7)[100.3–196.6] | 160.0 (20.2)[93.4–213.4] |
| Mean CRVE (µm) (SD) [range] | 202.0(19.5)[123.8–273.0] | 199.4 (19.2)[129.3–304.1] | 196.5 (19.2)[142.5–271.7] | 226.0 (20.1)[162.5–324.3] | 248.0 (19.0)[130.5–325.7] | 253.0 (28.6)[147.0–338.0] | 230.3 (21.7)[165.9–335.1] | 238.4 (24.0)[167.6–331.1] |
| Systolic blood pressure (mm Hg) (SD) [range] | 142.5(20.2)[92–253] | 122.9 (18.1)[75–226] | 134.4 (20.4)[82–241] | 138.5 (22.1)[74–250] | N/A | 130.5 (19.7)[85–210] | 130.5 (20.0)[71–248] | 146.0 (20.5)[95–240] |
| Diastolic blood pressure (mm Hg) (SD) [range] | 74.1 (20.2)[92–253] | 70.8 (10.0)[32–114] | 67.9 (10.8)[15–110] | 73.7 (11.4)[24–139] | N/A | 79.5 (11.9)[50–124] | 77.4 (10.8)[44–123] | 83.6 (9.8)[50–125] |
| Hypertension (%) | 80.6 | 35.3 | 48.7 | 42.3 | 3.2 | 41.7 | 35.1 | 46.1 |
| Diabetes mellitus (%) | 11.4 | 12.4 | 12.2 | 10.0 | 1.0 | 1.5 | 10.3 | 7.9 |
| Current smokers (%) | 12.5 | 17.3 | 6.2 | 23.6 | 11.0 | 13.8 | 21.6 | 12.4 |
| Body mass index (kg/m2) (SD) [range] | 27.1 (4.4)[14.8–48.5] | 28.0 (5.2)[14.2–59.1] | 26.8 (4.3)[15.6–46.7] | 26.3 (3.7)[14.2–50.7] | N/A | 25.6 (4.3)[15.0–48.2] | 28.3 (5.2)[15–55] | 26.3 (4.4)15.2–49.2 |
AGES: Age Gene/Environment Susceptibility – Reykjavik Study; ARIC: Atherosclerosis Risk in Communities Study; CHS: Cardiovascular Health Study; RS: Rotterdam Study; BDES: Beaver Dam Eye Study; BMES: Blue Mountains Eye Study; CRAE: central retinal arteriolar equivalent; CRVE: central retinal venular equivalent; SD: standard deviation; N/A Not available.