Table 2. Results for the five loci associated (p<5.0×10⁻⁸) with retinal venular caliber in the discovery cohorts both combined and individually.

	Discovery cohorts combined				Discovery cohorts individually
	CHARGE				AGES			ARIC			CHS			RS
SNP (chromosome position) locus	Minor allele (MAF)	Beta	SE	P-value	Beta	SE	P-value	Beta	SE	P-value	Beta	SE	P-value	Beta	SE	P-value	Genes of Interest	Other genes within 60kb	Additional SNPs at p-value<5×10−8
rs2287921 (53920084)19q13	T (0.47)	−2.0	0.23	3.30×10−18	−1.0	0.56	7.40×10−2	−2.5	0.36	3.80×10−12	−2.9	0.77	1.66×10−4	−1.7	0.42	5.17×10−5	RASIP1	IZUMO1, FUT1 FUT2, CA11 FGF21, FLJ36070	37
rs225717 (142589792)6q24	C (0.23)	−1.8	0.27	5.99×10−12	−1.9	0.60	1.54×10−3	−2.2	0.40	7.25×10−8	−2.0	0.96	3.70×10−2	−1.3	0.50	9.32×10−3	VTA1	NMBR	31
rs10774625 (110394602)12q24	A (0.48)	1.6	0.23	1.16×10−11	1.3	0.43	2.50×10−3	1.5	0.35	1.82×10−5	1.9	0.75	1.10×10−2	1.7	0.43	7.70×10−5	ATXN2	SH2B3, PTPN11	9
rs17421627 (87883342)5q14	G (0.08)	2.5	0.43	5.05×10−9	2.2	1.16	5.80×10−2	1.6	0.63	1.10×10−2	5.3	1.91	5.52×10−3	3.2	0.71	6.57×10−6	-	MEF2C	28
rs7824557 (11141521)8p23	G (0.39)	1.4	0.23	2.17×10−9	1.6	0.56	4.27×10−3	0.8	0.35	2.2×10−2	1.7	0.84	4.30×10−2	2.2	0.43	5.32×10−7	-	XKR6, PINX1 SOX7, MTMR9 GATA4	69

CHARGE: Cohorts for Heart and Aging Research in Genomic Epidemiology consortium; AGES: Age Gene/Environment Susceptibility – Reykjavik Study; ARIC: Atherosclerosis Risk in Communities Study; CHS: Cardiovascular Health Study; RS: Rotterdam Study; SNP: single nucleotide polymorphism; MAF: minor allele frequency; Beta: Change in retinal venular calibre for each copy of the minor allele; SE: standard error.