Table 4. The association between the four novel loci and cardiovascular diseases.
CHARGE (CRVE) | WTCCC (CAD) | HVH (stroke) | HVH (MI) | Global BPgen (HTN) | DIAGRAM+(DM) | |
12q24(rs10774625)M.A.: A | Beta: 1.6(SE 0.23)P = 1.16×10−11 | OR: 1.13 (1.03; 1.24) P = 0.008 | OR: 1.03(0.89; 1.20)P = 0.66 | OR: 1.05(0.94; 1.18)P = 0.39 | OR: 1.06 (1.01; 1.12) P = 0.019 | OR: 1.02(0.98; 1.06)P = 0.36 |
19q13 (rs2287921)M.A.: T | Beta: −2.0(SE 0.23)P = 3.30×10−18 | OR: 0.95(0.87; 1.05)P = 0.303 | OR: 0.90(0.77; 1.06)P = 0.20 | OR: 0.91(0.81; 1.03)P = 0.13 | OR: 1.01(0.96; 1.07)P = 0.67 | OR: 1.01(0.97; 1.05)P = 0.72 |
6q24(rs225717)M.A.: C | Beta: −1.8(SE 0.27)P = 5.99×10−12 | OR: 0.98(0.89; 1.08)P = 0.65 | OR: 1.11(0.93; 1.32)P = 0.24 | OR: 1.12(0.98; 1.27)P = 0.11 | OR: 0.98(0.93; 1.04)P = 0.55 | OR: 0.98(0.93; 1.02)P = 0.33 |
5q14(rs17421627)M.A.: G | Beta: 2.5(SE 0.43)P = 5.05×10−9 | OR: 1.02(0.88; 1.18)P = 0.81 | OR: 1.15(0.83; 1.59)P = 0.39 | OR: 1.02(0.79; 1.31)P = 0.89 | OR: 1.07(0.98; 1.17)P = 0.14 | OR: 0.98(0.91; 1.05)P = 0.60 |
CHARGE: Cohort for Heart and Aging Research in Genomic Epidemiology Consortium CRVE: central retinal venular equivalent (CRVE), SE: standard error; WTCCC: Wellcome Trust Case Control Consortium; CAD: coronary artery disease; HVH: Heart and Vascular Health Study; MI: myocardial infarction; Global BPgen: Global Blood Pressure Genetics Consortium; HTN: hypertension; DIAGRAM+: Diabetes Genetics Replication and Meta-analysis+; DM: diabetes mellitus; M.A.: Minor allele within CHARGE; OR: odds ratio (with corresponding 95% confidence interval) per copy of the minor allele.