Table 3. Comparison of properties of cholesterol-tagged peptides.
Short name | PEG linker | HPIV3 F derived HRC sequence | IC50 (nM) | |||
NiV | HPIV3 | |||||
infection* | fusion | infection | fusion | |||
V-chol | NO | 449-VALDPIDISIVLNKAKSDLEESKEWIRRSNQKLDSI-484 | ∼0.02 | ∼300 | ∼10.0 | >1000 |
V-PEG4-chol | YES | 449-VALDPIDISIVLNKAKSDLEESKEWIRRSNQKLDSI-484 | ∼0.02 | ∼80.0 | ∼0.70 | >1000 |
VIKI-PEG4-chol | YES | 449-VALDPIDISIVLNK I KSDLEESKEWIRRSNK I LDSI-484 | ∼0.02 | ∼5.0 | ∼0.30 | ∼30.0 |
*PSEUDOTYPE ASSAY.