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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: J Thromb Haemost. 2010 Apr 30;8(8):1670–1674. doi: 10.1111/j.1538-7836.2010.03893.x

Fig. 2.

Fig. 2

Poly P activates the kallikrein-kinin system and coagulation and inhibits fibrinolysis. Upon platelet activation, poly P is released from the dense granules to activate factor XII (FXII), which in turn activates prekallikrein (PK), consequently increasing bradykinin (BK) levels. Activated FXII also activates factor XI (FXI). By binding to thrombin (FII), poly P enhances thrombin-mediated factor V (FV) activation, promoting coagulation. In addition, Poly inhibits fibrinolysis by increasing TAFI activity and binding to fibrin (Fb) clots, making them more resistant to lysis.