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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Amino Acids. 2010 Apr 10;41(1):29–41. doi: 10.1007/s00726-010-0578-3

Fig. 1.

Fig. 1

Proposed metabolic pathways for naturally occurring organoselenium compounds. Dietary seleno amino acids can undergo either β-/γ-elimination reactions with formation of CH3SeH or transamination/oxidative deamination reactions with formation of seleno α-keto acids. CH3SeH from the former reaction is a putative anticancer metabolite of organoselenium compounds which can react with redox sensitive signal proteins. The α-keto acid metabolites from the latter reaction exhibit HDAC inhibitory properties in human prostate and colon cancer cells which is symbolized by ⊥