Table 3.
Proportion of MS cases and controls with variants in LMP1 as compared to B95.8 sequence
| Position | B95.8 | Variant | Cases N(%) | Controls N(%) |
|---|---|---|---|---|
| 212* | G | S‡ | 12 (22) | 8 (15) |
| 229 | S | T | 1 (2) | 2 (4) |
| 252 | G | A | 2 (4) | 1 (2) |
| 11aa repeats (253–303) | 4 repeats | 5 repeats | 6 (11) | 4 (7) |
| 5aa deletion (276–280) | not deleted | deleted‡ | 10 (19) | 9 (17) |
| 282 | D | G | 1 (2) | 2 (4) |
| 293 | D | G | 2 (4) | 2 (4) |
| 309 | S | N/D‡ | 10 (19) | 9 (17) |
| 317 | D | N/E | 1 (2) | 2 (4) |
| 322 | Q | N/E/T/H‡ | 10 (19) | 8 (15) |
| 328 | E | Q | 3 (6) | 0 |
| 334 | Q | R/H‡ | 8 (15) | 7 (13) |
| 338 | L | S/P‡ | 9 (17) | 8 (15) |
| 10aa deletion (343–352) | not deleted | deleted‡ | 6 (11) | 8 (15) |
| 352 | H | N/R‡ | 3 (6) | 2 (4) |
| 366 | S | T/A | 13 (24) | 9 (17) |
‡
Sequence differences found in the most common variant haplotype