Table II.
Activity for GSK690693 Against the PPTP in Vivo Panel
| Xenograft Line | Histology | P- value | EFS T/C | Median Final RTV | Tumor Volume T/C | P- value | T/C Activity | EFS Activity | Response Activity |
|---|---|---|---|---|---|---|---|---|---|
| BT-29 | Rhabdoid | 0.457 | 1 | >4 | 1.05 | 0.684 | Low | Low | Low |
| KT-14 | Rhabdoid | 0.24 | 1 | >4 | 0.78 | 0.315 | Low | Low | Low |
| KT-12 | Rhabdoid | 0.005 | > 3.8 | 3.4 | 0.65 | 0.077 | Low | Int | Int |
| KT-10 | Wilms | 0.265 | 1 | >4 | 0.93 | 0.684 | Low | Low | Low |
| KT-13 | Wilms | 0.924 | 1 | >4 | 0.95 | 0.971 | Low | Low | Low |
| SK-NEP-1 | Ewing | 0.819 | 0.9 | >4 | 1.05 | 0.497 | Low | Low | Low |
| EW5 | Ewing | 0.192 | 1.1 | >4 | 0.75 | 0.218 | Low | Low | Low |
| EW8 | Ewing | 0.123 | 1.6 | >4 | 0.76 | 0.035 | Low | Low | Int |
| TC-71 | Ewing | 0.183 | 0.8 | >4 | 1.29 | 0.156 | Low | Low | Low |
| CHLA258 | Ewing | 0.481 | 1 | >4 | 1.1 | 0.897 | Low | Low | Low |
| Rh10 | ALV RMS | 0.207 | 1.3 | >4 | 0.71 | 0.023 | Low | Low | Low |
| Rh28 | ALV RMS | <0.001 | 1.7 | >4 | 0.46 | <0.001 | Low | Low | Int |
| Rh30 | ALV RMS | 0.207 | 1.3 | >4 | 0.85 | 0.460 | Low | Low | Low |
| Rh30R | ALV RMS | 0.261 | 1 | >4 | 0.94 | 0.739 | Low | Low | Low |
| Rh41 | ALV RMS | 0.229 | 2 | >4 | 0.86 | 0.579 | Low | Low | Int |
| Rh65 | ALV RMS | 0.506 | 0.8 | >4 | 0.98 | 1.000 | Low | Low | Low |
| BT-28 | Medulloblastoma | 0.387 | 0.9 | >4 | 1.28 | 0.481 | Low | Low | Low |
| BT-45 | Medulloblastoma | 0.787 | 1.1 | >4 | 0.95 | 0.780 | Low | Low | Low |
| BT-50 | Medulloblastoma | 0.341 | > 1.0 | 3.6 | 1.01 | 0.631 | Low | NE | Int |
| BT-44 | Ependymoma | 0.049 | 1.5 | >4 | 0.71 | 0.011 | Low | Low | Low |
| GBM2 | Glioblastoma | 0.016 | 1.8 | >4 | 0.79 | 0.165 | Low | Low | Int |
| BT-39 | Glioblastoma | 0.237 | 1.1 | >4 | 0.94 | 0.218 | Low | Low | Low |
| D645 | Glioblastoma | <0.001 | 1.4 | >4 | 0.64 | 0.003 | Low | Low | Low |
| D456 | Glioblastoma | 0.077 | 1.2 | >4 | 0.84 | 0.089 | Low | Low | Low |
| NB-1771 | Neuroblastoma | <0.001 | 1.2 | >4 | 0.69 | 0.182 | Low | Low | Low |
| NB-1691 | Neuroblastoma | 0.672 | 1 | >4 | 1.18 | 0.815 | Low | Low | Low |
| NB-EBc1 | Neuroblastoma | 0.473 | 0.7 | >4 | 1.82 | 0.123 | Low | Low | Low |
| CHLA-79 | Neuroblastoma | 0.474 | 0.9 | >4 | 0.99 | 0.905 | Low | Low | Low |
| OS-1 | Osteosarcoma | <0.001 | > 1.4 | 2.8 | 0.65 | 0.015 | Low | NE | Int |
| OS-2 | Osteosarcoma | 0.006 | 1.5 | >4 | 0.6 | 0.002 | Low | Low | Low |
| OS-17 | Osteosarcoma | 0.028 | 1.3 | >4 | 0.71 | 0.029 | Low | Low | Low |
| OS-9 | Osteosarcoma | 0.014 | 1.4 | >4 | 0.68 | 0.011 | Low | Low | Low |
| OS-33 | Osteosarcoma | <0.001 | 2.7 | >4 | 0.21 | <0.001 | Int | Int | Int |
| OS-31 | Osteosarcoma | 0.002 | 1.2 | >4 | 0.82 | 0.002 | Low | Low | Low |
| ALL-2 | ALL B-precursor | 0.454 | 1.5 | >25 | . | Low | Int | ||
| ALL-3 | ALL B-precursor | 0.199 | 1.4 | >25 | . | Low | Low | ||
| ALL-4 | ALL B-precursor | 0.739 | 1.4 | >25 | . | Low | Low | ||
| ALL-7 | ALL B-precursor | 0.481 | 2.3 | >25 | . | Low | Int | ||
| ALL-8 | ALL T-cell | 0.935 | 1.2 | >25 | . | Low | Low | ||
| ALL-16 | ALL T-cell | 0.816 | 0.7 | >25 | . | Low | Low | ||
| ALL-17 | ALL B-precursor | 0.841 | 0.8 | >25 | . | Low | Low | ||
| ALL-19 | ALL B-precursor | 0.513 | 1.4 | >25 | . | Low | Low |