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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Hum Vaccin. 2010 Jun 1;6(6):482–492. doi: 10.4161/hv.6.6.11562

Fig. 2.

Fig. 2

MPL blunts the “cytokine storm” associated with FI-RSV vaccine-enhanced disease. Cotton rats were vaccinated i.m. with FI-RSV alone (FI) or in combination with MPL (FI +MPL). Control animals were vaccinated with a mock vaccine (mock) or infected with RSV (RSV IN). After RSV challenge of all groups, animals were sacrificed at the indicated times and lung samples analyzed for expression of Th2 and Th1 cytokine mRNA as described in Fig. 3. Results represent the mean ± S.E.M. for 4 – 6 animals per time point. #, p < 0.05; *, p < 0.01; X, p < 0.001 (FI + MPL vs. FI treatment). Adapted from reference80.