Skip to main content
. 2010 Jul 9;1(3):185–197. doi: 10.18632/oncotarget.125

Fig. 2: The effect of the Hsp90 inhibitor 17-AAG on 1H MRS detectable cellular choline metabolites in human melanoma cell lines.

Fig. 2:

A) 1H MR spectra from the aqueous phase of cell extracts showing the choline region in control and 17-AAG treated SKMEL28 (left) and CHL-1 (right) cells.

B) A histogram showing increased GPC content following 17-AAG treatment in SKMEL28 and CHL-1 cells while PC levels remain unchanged.

C) A histogram showing decreased PC/GPC in 17-AAG treated SKMEL28 and CHL-1 cells relative to their vehicle-treated controls. **p<0.01.