Table 3. Risk of non-breast cancer for parents and siblings of index casesa.

	Observed	Expected	SIR (95% CI)
Parents and siblings	143	72.44	1.97 (1.68–2.33)
Fathers and brothers	79	38.15	2.07 (1.66–2.58)
Mothers and sisters	64	34.29	1.87 (1.46–2.38)
Parents	114	62.34	1.83 (1.52–2.20)
Siblings	29	10.10	2.87 (2.00–4.13)
Fathers	69	33.05	2.09 (1.65–2.64)
Mothers	45	29.30	1.54 (1.15–2.06)
Brothers	10	5.11	1.96 (1.05–3.64)
Sisters	19	4.99	3.80 (2.43–5.96)
San Francisco	41	16.49	2.49 (1.83–3.38)
Ontario	33	17.10	1.93 (1.37–2.72)
Melbourne and Sydney	69	38.86	1.78 (1.40–2.25)
Index case: BRCA1 positive	8	3.94	2.03 (1.02–4.06)
Index case: BRCA2 positive	5	2.75	1.82 (0.76–4.36)
Index case: negative	107	54.46	1.97 (1.63–2.38)
Index case: untested	23	11.40	2.02 (1.34–3.04)
Index case: negative – fathers and brothers	58	28.40	2.04 (1.58–2.64)
Index case: negative – mothers and sisters	49	22.06	1.88 (1.42–2.49)
Index case: negative – parents	83	46.33	1.79 (1.45–2.22)
Index case: negative – siblings	24	8.13	2.95 (1.98–4.41)
Index case: negative – fathers	50	24.34	2.05 (1.56–2.71)
Index case: negative – mothers	33	21.99	1.50 (1.07–2.11)
Index case: negative – brothers	8	4.06	1.97 (0.98–3.94)
Index case: negative – sisters	16	4.07	3.93 (2.41–6.42)

Abbreviations: CI=confidence interval; SIR=standardised incidence ratio.

^aExcludes non-melanoma skin cancer.