Figure 1.

Simulation results where tail domain binding events are included. (A) Initial configuration in which 1-μm-long filaments are randomly distributed. (B) Configuration after 10⁶ steps, or 43.2 ms. (C) RMSD for translation after 10⁶ steps, or 43.2 ms. (D) Number of paired filaments after 10⁶ steps, or 43.2 ms. (E) Distribution of filament connectivity in the initial configuration. (F) Distribution of filament connectivity in the final configuration. The outcome of these simulations suggests that tail domain binding events are not sufficient to foster the formation of crosslinked networks as seen experimentally.