Flow chart of the COMBCON and TASSER_WT algorithms. The COMBCON algorithm is delineated by the dashed lines. A given protein sequence is subject to the four threading algorithms, PROSPECTOR_3.5, PROSPECTOR_4, STITCH_high, and STITCH_low, and the resulting set of contacts are weighted by the total frequency of occurrence in the four methods. These frequency-weighted contacts are then provided to the TASSER_WT structure assembly algorithm along with the set of PROSPECTOR_4-provided template alignments.