Table 1.
Incidence of cataracts and the levels of ATP and GSH in the lenses of rat pups injected with sodium selenite (B) and sodium selenite plus caffeine (C). Experimental details are described in the text. The division of group C between two groups was done after looking at the extent of opacity in the animals treated with caffeine, the ones having less clarity were groups under C2. In the first row, the numbers without parentheses indicate the number of eyes. Numbers in parentheses indicate the corresponding number of animals. The # of animals in the selenite only and Selenite + caffeine were 11 in each. P values between A& B, B&C1 and C2&B are <0.001, except in the case of ATP between C2 & B, which was not significant.
| A: Normal (no cataract) |
B: Sel (advanced cataract) |
C1:Sel + caff: no cataract |
C2: Sel + caff: moderate cataract |
|
|---|---|---|---|---|
| # of eyes (# of animals) | 8 (4) | 22 (11) | 14 (7) | 8 (4) |
| ATP µmoles/g | 2.5 ± 0.04 | 1.0 ± 0.2 | 1.6 ± 0.2 | 1.05 ± 0.07 |
| GSH µmoles/g | 8.2 ± 0.4 | 2.0 ± 0.86 | 5.8 ±1.4 | 3.6 ± 0.8 |