Table 1.

Microarray and Validation Cohort subject demographics. SSc‐PAH and SSc without PAH have a statistically significant difference in age (p= 0.03) in the Microarray and Validation Cohorts. There was no statistical difference in hemodynamic values between the two cohorts. NHW= Non‐Hispanic White; AA= African American; HL= Hispanic Latino; AS= Asian. TTE= transthoracic echo; RAP= right atrial pressure; RVSP= right ventricular systolic pressure; TR Jet= tricuspid regurgitant jet. mPAP= mean pulmonary artery pressure, PVR= pulmonary vascular resistance, CO= cardiac output; CI= cardiac index. All values are expressed as mean ± standard deviation.

Cohort	Microarray			Validation
Subjects	SSc‐PAH	SSc without PAH	p value	SSc‐PAH	SSc without PAH	p value
n	10	10		15	19
Age (years)	61.7 ± 9.4	51.2 ± 11.0	0.03	59.3 ± 10.1	51.0 ± 8.5	0.014
Ethnicity (number)
NHW	10	6		12	14
AA	0	1		2	2
HL	0	1		1	3
AS	0	1		0	0
Unknown	0	1		0	0
Gender (% female)	100	100		86.7	84.2
Oral Pulmonary hypertension therapy (%)	100	n/a		100	n/a
WHO functional class	2.7 ± 0.5			2.5 ± 0.8		0.44
6 MWD (m)	301.5 ± 100.0			300.9 ± 91.9		0.99
Pulmonary function tests
Dlco (%)	39.6 ± 15.7	70.6± 29.4	0.02	35.6± 18.8	78.6 ± 33.8	0.001
FVC/DLco	2.3 ± 0.9	1.4 ± 0.5	0.03	2.1± 0.8	1.2 ± 0.3	0.001
FVC (%)	79.3 ± 13.7	86.6 ± 13.9	0.28	63.4 ± 11.1	89.1 ± 16.1	<0.0001
Transthoracic echo data
RAP (mmHg)	7.2 ± 3.3			7.3 ± 3.7		0.97
RVSP (mmHg)	80.2 ± 20.3			67.6 ± 29.8		0.28
TR Jet(m/s2)	4.2 ± 0.6			3.8 ± 0.8		0.17
Right heart catheterization data
RAP (mmHg)	5.4 ± 3.7			4.8 ± 3.1		0.67
mPAP (mmHg)	42.9 ± 9.8			39.1 ± 8.0		0.29
PVR (WU)	8.0 ± 4.4			7.0 ± 2.8		0.51
CO (L/min)	4.8 ± 1.6			4.9 ± 1.7		0.90
CI (L/min/m2)	2.5 ± 0.9			2.7 ± 0.8		0.75