TABLE 1.
Hydrolysis of PSI-7851 by various enzymes
| Enzyme | Type | Source | Activity |
|---|---|---|---|
| nmol/min/μg | |||
| Trypsin | Serine protease | Pancreas | NDa |
| Chymotrypsin | Serine protease | Pancreas | ND |
| Chymase | Serine protease | Skin | ND |
| Elastase | Serine protease | Neutrophil | 6.5 |
| Cathepsin A | Serine protease | Recombinant | 27.0 |
| Cathepsin B | Cysteine protease | Liver | ND |
| Cathepsin D | Aspartic protease | Liver | ND |
| Cathepsin H | Cysteine protease | Liver | ND |
| Cathepsin L | Cysteine protease | Liver | ND |
| Carboxylesterase 1 | Serine esterase | Recombinant | 1.8 |
| Carboxylesterase 2 | Serine esterase | Recombinant | ND |
| Calpain 1 | Cysteine protease | Plasma | ND |
| Caspase 1–10 | Cysteine protease | Recombinant | ND |
| Lipase | Serine esterase | Pancreas | ND |
a ND means not detected after a 2-h incubation with 100 μm of PSI-7851.