TABLE 2.
Age | Base |
Apex |
||||
---|---|---|---|---|---|---|
Control | Retigabine | Control | Retigabine | |||
Spike number | 2 weeks (n = 4) | 29 ± 12 | 2 ± 1 | n = 5 | 1 ± 0 | 0a |
3–4 months (n = 7) | 20 ± 6 | 0.4 ± 0.5a | n = 8 | 1 ± 0 | 0a | |
17 months (n = 5) | 22 ± 6 | 1 ± 1a | n = 6 | 1 ± 0 | 0a | |
Rmp (mV) | 2 weeks (n = 4) | −58 ± 2 | −64 ± 1b | n = 5 | −66 ± 4 | −75 ± 5b |
3–4 months (n = 7) | −59 ± 3 | −66 ± 3b | n = 8 | −62 ± 2 | −66 ± 3 | |
17 months (n = 5) | −59 ± 3 | −69 ± 2a | n = 6 | −61 ± 2 | −67 ± 2b | |
AP duration (ms) | 2 weeks (n = 4) | 7 ± 1 | n = 4 | 6 ± 2 | ||
3–4 months (n = 7) | 8 ± 2 | n = 7 | 8 ± 1 | |||
17 months (n = 5) | 6 ± 2 | 3 ± 0a | n = 6 | 7 ± 1 |
a p < 0.01 treatment versus control.
b p < 0.05.