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. 2010 Aug 25;285(45):34699–34707. doi: 10.1074/jbc.M110.136192

TABLE 2.

Effects of retigabine on membrane properties of SGNs

Rmp is resting membrane potential.

Age Base
Apex
Control Retigabine Control Retigabine
Spike number 2 weeks (n = 4) 29 ± 12 2 ± 1 n = 5 1 ± 0 0a
3–4 months (n = 7) 20 ± 6 0.4 ± 0.5a n = 8 1 ± 0 0a
17 months (n = 5) 22 ± 6 1 ± 1a n = 6 1 ± 0 0a
Rmp (mV) 2 weeks (n = 4) −58 ± 2 −64 ± 1b n = 5 −66 ± 4 −75 ± 5b
3–4 months (n = 7) −59 ± 3 −66 ± 3b n = 8 −62 ± 2 −66 ± 3
17 months (n = 5) −59 ± 3 −69 ± 2a n = 6 −61 ± 2 −67 ± 2b
AP duration (ms) 2 weeks (n = 4) 7 ± 1 n = 4 6 ± 2
3–4 months (n = 7) 8 ± 2 n = 7 8 ± 1
17 months (n = 5) 6 ± 2 3 ± 0a n = 6 7 ± 1

a p < 0.01 treatment versus control.

b p < 0.05.