FIGURE 2.

Oligomeric but not fibrillar Aβ attenuates the acquisition of in vitro classical conditioning. A, physiological records of abducens nerve recordings taken from experiments in which brainstems were treated with oligomeric or fibrillar Aβ. Both traces show an abducens nerve unconditioned response recorded in the second pairing session after Aβ application. A CR is indicated (arrow) in the record from a preparation treated with fibrillar Aβ. The CS and US are indicated at bottom. B, acquisition curves of the percentage of CRs during the acquisition phase of conditioning. Oligomeric (Oligo), but not fibrillar or scrambled Aβ peptides, significantly suppressed acquisition of CRs as compared with normal conditioning. Asterisks indicate significant differences from pseudoconditioning (p values under “Results”).