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Dose-response signaling curves of the three GpHRs, WT, and mutant forms in β-strand 5. Representative cAMP responses are shown for the WT receptors and mutant forms harboring replacements of Asp150 (FSHR), Glu154 (LHR), and Glu157 (TSHR) upon receptor activation with the cognate hormones (hCG being used to activate LHR; h is human). All assays of intracellular cAMP were done by RIA with HEK 293 cells.
