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. 2010 Aug 31;285(45):35092–35103. doi: 10.1074/jbc.M109.088625

FIGURE 2.

FIGURE 2.

The D1-D2 receptor heteromer-mediated calcium signal is desensitized by prior treatment with dopamine agonists for 5 min. A, representative calcium tracings displaying the calcium signal activated by 10 μm dopamine (control) and after pretreatment with 1 μm SKF 83959 for 5 min in D1-D2 receptor stably expressing cells. Dose-response curves demonstrate the percentage reduction in peak calcium levels after pretreatment with increasing concentrations of SKF 81297 (B), SKF 83959 (C), or SKF 83822 (D) from 10−11 to 10−4 m for 5 min, washed, and activated with 10 μm dopamine. Values shown are the means ± S.E. of n = 3–6 experiments.