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. 2010 Aug 31;285(45):35092–35103. doi: 10.1074/jbc.M109.088625

FIGURE 5.

FIGURE 5.

The D1-D2 receptor heteromer-mediated calcium signal is desensitized in striatal neurons by prior treatment with dopamine agonists for 30 min. A, peak FRET levels correspond to rises in intracellular calcium by activation with 100 nm dopamine and after pretreatment with 100 nm SKF 83959 or 100 nm SKF 83822 for 30 min. B, peak FRET levels correspond to rises in intracellular calcium by activation with 100 nm dopamine and after pretreatment with 100 nm SKF 83822 without and with 10 μΜ SQ 22536 or 10 μΜ H-89. Peak FRET levels correspond to rises in intracellular calcium by activation with 100 nm dopamine and after pretreatment with 100 nm SKF 83959 (C) or 100 nm SKF 83822 (D) without and with 10 μm raclopride or 10 μm SCH 23390. The results shown represent the means ± S.E. of values from the number of cells shown. A significant difference from control (no pretreatment) is denoted by * = p < 0.05.