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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Curr Protoc Neurosci. 2010 Apr;CHAPTER:Unit–9.1226. doi: 10.1002/0471142301.ns0912s51

Figure 9.12.4.

Figure 9.12.4

(A) Mean ± SEM ethanol intake (g/kg) by dependent (closed circles) and non-dependent (open circles) Wistar rats during pre-vapor baseline period (BASE) versus three intermittent (INT; white background) and three consecutive-days (CON; gray background) operant test sessions that occurred 6 hours into acute withdrawal; and also (B) during pre-vapor baseline period (BASE) versus three (24 hrs, 48 hrs, 72 hrs) early-abstinence (white background), three (7 days, 8 days, 9 days) middle-abstinence (light gray background), and two (14 days, 15 days) protracted-abstinence (dark gray) operant test sessions. Dependent rats exhibit significant and reliable increase in ethanol intake relative to non-dependent rats.