Figure 9.12.7.

Mean ±SEM alcohol intake (g/kg) by animals in the alcohol binge group (n=11; left panel) and supersac intake (ml/kg) by supersac controls (n=12; right panel) following pretreatment with (A) one of four doses (0, 2, 4, 8 mg/kg) of duloxetine (i.p. injection 40 min prior to drinking session), (B) one of five doses (0, 16, 50, 150, 450 μg/kg) of naltrexone (s.c. injection 30 min prior to drinking session), or (C) one of four doses (0, 5, 10, 20 mg/kg) of MPZP (s.c. injection 60 min prior to drinking session). *p< 0.05, **p< 0.01 significant difference from vehicle condition.