Fig. 13.

Two biopsies from a hepatic homograft. The first (A) was taken after the host had been receiving azathioprine for 121 days. The lobular architecture is distorted by thick bands of connective tissue which link portal tracts to each other and to central veins. Hepatocytes in the pseudolobules of regenerating liver contain much lipid. Azathioprine therapy was then discontinued, and 77 days later, 198 days after transplantation, the second biopsy (B) was taken. There has been a striking improvement in the general liver architecture. Connective tissue bands are no longer so obvious and the liver cells look more healthy. (Hematoxylin and eosin. Original magnification ×40.)