Fig. 14.

Two biopsies from a hepatic homograft. The first (A) was taken after the dog had been treated with azathioprine for 123 days. There is some increase in portal connective tissue, proliferation of small biliary ductules, and a slight cellular infiltration. Treatment with immunosuppressive drugs was stopped, and 84 days later, 207 days after transplantation, the second biopsy (B) was taken. There has been a marked deterioration. The portal tracts are very heavily infiltrated with a mixture of mononuclear and neutrophilic leukocytes. (Hematoxylin and eosin. Original magnification ×40)