Table 1. Kinetic parameters of OGG1, APE1 and Nfo.

Enzyme	Substrate	Activity	Kmapp (nM)	kcatapp ×103 (min–1)
OGG1	8-oxoG·C	Glycosylase	9.9 ± 0.2	108 ± 7.1
OGG1 + APE1	8-oxoG·C	Glycosylase	8.9 ± 0.9	453 ± 16
OGG1	AP site	AP lyase	7.2 ± 1.1	53.2 ± 7
APE1	AP site	AP endonuclease	13.7 ± 1.2	21, 671 ± 2132
Nfo	AP site	AP endonuclease	21.2 ± 2.2	1062 ± 90

Values were calculated from Lineweaver–Burke plots of data presented in Figures 1 and 7.