The stress balance hypothesis. The GAG and COL constituents have their own reference configurations, . The GAG constituent has the same configuration in and κ0, which is equivalent to and eSGAG(0) = −α1I. To balance this swelling stress, the COL network supports a tensile prestress produced by an initial COL deformation gradient tensor, , which yields the initial collagen stress tensor, eSCOL(0) = α1I. After a deformation F is applied, the constituent stresses are calculated relative to their respective reference configurations and using .