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. Author manuscript; available in PMC: 2011 Sep 24.
Published in final edited form as: FEBS Lett. 2010 Aug 6;584(18):3985–3989. doi: 10.1016/j.febslet.2010.08.002

Fig. 4.

Fig. 4

ERK 1/2 regulates AFR in rat lungs exposed to high pCO2. Anesthetized Sprague Dawley rats were pre-treated with 5 mg/kg U0126 or DMSO (I.V.) 30 min prior to the isolated-perfused rat lung model. (A) Isolated rats lungs were perfused for 1 h with 40 mmHg pCO2 (black bars) or with approximately 60 mmHg pCO2 (grey bars) and AFR was measured. (B) Passive fluxes of 22Na+ (black bars) and 3H-mannitol (white bars) were measured. Bars represent the mean ± S.E.M, n = 5. **P < 0.01.