Table 5. Summary of sensitivity and specificity of malaria LAMP assays reported in the literature.
Reference test | Poon et al. [16] | Paris et al. [15] | Han et al. [14] | Chen et al. [13] | Yamamura et al. [17] | RealAmp# |
Microscopy (parasitemia)* | Not reported | Not reported | 210–24,164p/µL | Not reported | 0.06–6.12% parasitemia | 61–248960 p/µL |
Sensitivity (%) | 73.1 | 94.3 | 98.3 | 97.8 | 96.7 | |
Specificity (%) | 100 | 98.5 | 100 | 85.7 | 91.7 | |
Nested PCR | ||||||
Sensitivity (%) | 95** | 76.1/79.1** | 98.8 | |||
Specificity (%) | 99** | 89.6/58.3** | 100 | |||
HRP-II RDT | ||||||
Sensitivity (%) | 77.6 | |||||
Specificity (%) | 100 |
*As reported by the authors.
**In these studies DNA amplification was performed using heat treated whole blood.
Results from the current study.