Table 3. Immunogenicity Data for Adults.
Baseline seronegative | All recipients | ||||||||
Day 0 n = 200, 45 * | Day 15 n = 101, 26 * | Day 29 n = 99, 19 * | Day 57 n = 189, 42 * | Day 0 n = 235, 59 * | Day 15 n = 120, 30 * | Day 29 n = 115, 29 * | Day 57 n = 222, 54 * | ||
GMT | |||||||||
Vaccine | 2.15 | 2.42 | 2.57 | 3.65 | 3.00 | 3.46 | 3.44 | 4.86 | |
Placebo | 2.09 | 2.00 | 2.31 | 2.48 | 3.64 | 2.64 | 4.96 | 3.90 | |
Seroconversion rate,% | |||||||||
Vaccine | NA | 3.0 | 7.1 | 16.9 | NA | 2.5 | 6.1 | 14.9 | |
Placebo | NA | 0.0 | 0.0 | 7.1 | NA | 0.0 | 0.0 | 5.6 | |
GMT ≥32, n (%) | |||||||||
Vaccine | 14 (7.4) | 30 (13.5) | |||||||
Placebo | 1 (2.4) | 6 (11.1) | |||||||
Rate difference, % , (95% CI) | 5.0(–4.9, 10.7) | 2.4(–9.3, 10.8) |
GMFR = geometric mean fold rise; GMT = geometric mean titer; NA = not applicable.
*All n’s are presented as vaccine, placebo.