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. 2010 Oct 29;5(10):e13751. doi: 10.1371/journal.pone.0013751

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Barron et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Serial sections showing stromal thickening (Panel A, arrow) with increased deposition of tenascin-C (Panel B, IHC for tenascin-C), consistent with a reactive stroma phenotype in areas surrounding some attenuated epithelial acini. Panel C. Tenascin-C immunoreactivity is also deposited near the base of stromal micronodules. Panel D and E. Tenascin-C deposition appears to form lamellar layers near the base and periphery of stromal micronodules. Panel F. Masson's trichrome staining indicates nodules are composed of collagen (blue). Images A–D & F were captured at ×200 and image E at ×400 magnification.