Figure 6. Cytokine production in sera, lungs and spleens of mice upon MHV-68 treatment.
WT, TLR2−/− and MyD88−/− mice were injected iv. with mock control or UV-irradiated MHV-68 particles and sacrificed at 10 or 24 hours post-treatment. Concentration levels of IL-6 and IFN-α were determined by ELISA in sera, lung and spleen homogenates after 24 hours. IFN-β levels were tested at 10 hours post-treatment. Data are representative of two different experiments. Values significantly different (p<0.05) from WT mice are indicated by (*). N.D.: not detected.