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. 2010 Oct 29;5(10):e13774. doi: 10.1371/journal.pone.0013774

Figure 2. Expression of c-Fos protein in neurons of the spinal cord of bone cancer-bearing animals 14 days after implantation into the femur.

Figure 2

(A) Photomicrograph of an L3 section of the spinal cord of a tumor-bearing rat depicting c-Fos protein's global expression profile. (B–C) High magnification of the ipsilateral and contralateral dorsal horn laminae V-VI, respectively. Black arrowheads point to c-Fos proteins only in the ipsilateral limb. (D–E) Histogram representations of Fos-LI neurons per laminae in cancer animals for ipsilateral and contralateral sides, respectively. Data are mean ± S.E.M. number of Fos-LI neurons in the different spinal cord segments for sham and cancer rats (Scale bars, A: 200 µm; B,C: 30 µm; n = 23 sections from 3 rats/group; *: p≤0.05; ***: p≤0.001).