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. 2010 Oct 29;5(10):e13764. doi: 10.1371/journal.pone.0013764

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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A) RT-PCR analysis demonstrating up-regulation of LOC554202 expression in SAEC following 5-day CSC exposure. Consistent with data pertaining to up-regulation of miR-31 by CSC, expression of LOC554202 persisted for 20 days following cessation of CSC exposure. B) qRT-PCR analysis demonstrating expression levels of LOC554202 in primary lung cancers relative to adjacent normal lung tissues. C) Schematic representation of LOC554202, the putative host gene of miR-31. A, B, C, and D represent positions of paired primers used for ChIP analysis. D) ChIP analysis depicting H3K4Me3 and H3K9/14 acetylation levels within four regions of the LOC554202 promoter (∼1 kb, 2 kb, 3 kb, and, 5 kb from the TSS) in SAEC cultured with or without CSC. Increased activation marks were observed in the proximal promoter region following CSC exposure.